Rheumatology
Kelley and Firestein’s Textbook of Rheumatology 10th
Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.
An ideal balance of the basic science you need to know and how to apply that information to clinical practice.
An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.
Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.
New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.
More schematic diagrams clearly summarize information and facilitate understanding.
Table of contents :
Content:
Front Matter,Copyright,Dedication,Acknowledgement,Contributors,PrefaceEntitled to full textVolume 1Part I: Structure and Function of Bone, Joints, and Connective TissueChapter 1 - Biology of the Normal Joint, Pages 1-19.e4
Chapter 2 - Synovium, Pages 20-33
Chapter 3 - Cartilage and Chondrocytes, Pages 34-59.e3
Chapter 4 - Biology, Physiology, and Morphology of Bone, Pages 60-65
Chapter 5 - Muscle: Anatomy, Physiology, and Biochemistry, Pages 66-77
Chapter 6 - Biomechanics, Pages 78-89
Chapter 7 - Regenerative Medicine and Tissue Engineering, Pages 90-105.e4
Chapter 8 - Proteinases and Matrix Degradation, Pages 106-125
Chapter 9 - Dendritic Cells: General Overview and Role in Autoimmunity, Pages 126-144.e6
Chapter 10 - Mononuclear Phagocytes, Pages 145-168.e3
Chapter 11 - Neutrophils, Pages 169-188.e3
Chapter 12 - T Lymphocytes, Pages 189-206
Chapter 13 - B Cells, Pages 207-230.e3
Chapter 14 - Fibroblasts and Fibroblast-like Synoviocytes, Pages 231-249.e4
Chapter 15 - Mast Cells, Pages 250-263.e4
Chapter 16 - Platelets, Pages 264-273.e3
Chapter 17 - Innate Immunity, Pages 274-287
Chapter 18 - Adaptive Immunity and Organization of Lymphoid Tissues, Pages 288-300
Chapter 19 - Autoimmunity, Pages 301-317.e5
Chapter 20 - Metabolic Regulation of Immunity, Pages 318-326
Chapter 21 - Genetics of Rheumatic Diseases, Pages 327-343
Chapter 22 - Epigenetics of Rheumatic Diseases, Pages 344-354
Chapter 23 - Complement System, Pages 355-365
Chapter 24 - Prostaglandins, Leukotrienes, and Related Compounds, Pages 366-383.e3
Chapter 25 - Cell Recruitment and Angiogenesis, Pages 384-395.e5
Chapter 26 - Cytokines, Pages 396-407
Chapter 27 - Principles of Signaling, Pages 408-417
Chapter 28 - Immunologic Repercussions of Cell Death, Pages 418-448.e6
Chapter 29 - Experimental Models for Rheumatoid Arthritis, Pages 449-460
Chapter 30 - Neuronal Regulation of Pain and Inflammation, Pages 461-474.e3
Chapter 31 - Clinical Research Methods in Rheumatic Disease, Pages 475-485
Chapter 32 - Economic Burden of Rheumatic Diseases, Pages 486-495
Chapter 33 - Assessment of Health Outcomes, Pages 496-508
Chapter 34 - Biologic Markers in Clinical Trials and Clinical Care, Pages 509-519
Chapter 35 - Occupational and Recreational Musculoskeletal Disorders, Pages 520-532
Chapter 36 - Cardiovascular Risk in Inflammatory Rheumatic Disease, Pages 533-546.e5
Chapter 37 - Cancer Risk in Rheumatic Diseases, Pages 547-559
Chapter 38 - Introduction to Physical Medicine, Physical Therapy, and Rehabilitation, Pages 560-571
Chapter 39 - Pregnancy and Rheumatic Diseases, Pages 572-586
Chapter 40 - History and Physical Examination of the Musculoskeletal System, Pages 587-604
Chapter 41 - Acute Monoarthritis, Pages 605-614
Chapter 42 - Evaluation and Differential Diagnosis of Polyarthritis, Pages 615-624
Chapter 43 - Skin and Rheumatic Diseases, Pages 625-644
Chapter 44 - The Eye and Rheumatic Diseases, Pages 645-653
Chapter 45 - Neck Pain, Pages 654-668
Chapter 46 - Shoulder Pain, Pages 669-695.e4
Chapter 47 - Low Back Pain, Pages 696-716
Chapter 48 - Hip and Knee Pain, Pages 717-733
Chapter 49 - Foot and Ankle Pain, Pages 734-741
Chapter 50 - Hand and Wrist Pain, Pages 742-755.e3
Chapter 51 - Temporomandibular Joint Pain, Pages 756-767
Chapter 52 - Fibromyalgia, Pages 768-783.e3
Chapter 53 - Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, Pages 784-801.e4
Chapter 54 - Arthrocentesis and Injection of Joints and Soft Tissue, Pages 802-816
Chapter 55 - Anti-nuclear Antibodies, Pages 817-830
Chapter 56 - Autoantibodies in Rheumatoid Arthritis, Pages 831-845.e5
Chapter 57 - Acute Phase Reactants and the Concept of Inflammation, Pages 846-857.e4
Chapter 58 - Imaging in Rheumatic Diseases, Pages 858-907.e8
Chapter 59 - Biology and Therapeutic Targeting of Prostanoids, Pages 908-931.e4
Chapter 60 - Glucocorticoid Therapy, Pages 932-957.e5
Chapter 61 - Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, Pages 958-982.e7
Chapter 62 - Immunosuppressive Drugs, Pages 983-998.e4
Chapter 63 - Anti-cytokine Therapies, Pages 999-1019
Chapter 64 - Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, Pages 1020-1043.e4
Chapter 65 - Novel Intra-cellular Targeting Agents in Rheumatic Disease, Pages 1044-1060
Chapter 66 - Urate-Lowering Therapy, Pages 1061-1074.e3
Chapter 67 - Analgesic Agents in Rheumatic Disease, Pages 1075-1095
Chapter 68 - Nutrition and Rheumatic Diseases, Pages 1096-1114.e5
Chapter 69 - Etiology and Pathogenesis of Rheumatoid Arthritis, Pages 1115-1166.e7
Chapter 70 - Clinical Features of Rheumatoid Arthritis, Pages 1167-1186
Chapter 71 - Treatment of Rheumatoid Arthritis, Pages 1187-1212.e5
Chapter 72 - Early Synovitis and Early Undifferentiated Arthritis, Pages 1213-1220
Chapter 73 - Sjögren's Syndrome, Pages 1221-1244.e4
Chapter 74 - Etiology and Pathogenesis of Spondyloarthritis, Pages 1245-1255.e4
Chapter 75 - Ankylosing Spondylitis, Pages 1256-1279.e5
Chapter 76 - Undifferentiated Spondyloarthritis, Pages 1280-1284
Chapter 77 - Psoriatic Arthritis, Pages 1285-1308.e4
Chapter 78 - Enteropathic Arthritis, Pages 1309-1328
Chapter 79 - Etiology and Pathogenesis of Systemic Lupus Erythematosus, Pages 1329-1344
Chapter 80 - Clinical Features of Systemic Lupus Erythematosus, Pages 1345-1367.e3
Chapter 81 - Treatment of Systemic Lupus Erythematosus, Pages 1368-1388.e5
Chapter 82 - Anti-phospholipid Syndrome, Pages 1389-1399
Chapter 83 - Etiology and Pathogenesis of Scleroderma, Pages 1400-1423.e3
Chapter 84 - Clinical Features and Treatment of Scleroderma, Pages 1424-1460.e5
Chapter 85 - Inflammatory Diseases of Muscle and Other Myopathies, Pages 1461-1488.e5
Chapter 86 - Overlap Syndromes, Pages 1489-1511.e4
Chapter 87 - Classification and Epidemiology of Systemic Vasculitis, Pages 1512-1519
Chapter 88 - Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis, Pages 1520-1540
Chapter 89 - Anti-neutrophil Cytoplasmic Antibody–Associated Vasculitis, Pages 1541-1558.e4
Chapter 90 - Polyarteritis Nodosa and Related Disorders, Pages 1559-1570
Chapter 91 - Immune Complex–Mediated Small-Vessel Vasculitis, Pages 1571-1580
Chapter 92 - Primary Angiitis of the Central Nervous System, Pages 1581-1588
Chapter 93 - Behçet's Disease, Pages 1589-1596
Chapter 94 - Etiology and Pathogenesis of Hyperuricemia and Gout, Pages 1597-1619.e6
Chapter 95 - Clinical Features and Treatment of Gout, Pages 1620-1644.e4
Chapter 96 - Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, Pages 1645-1665.e4
Chapter 97 - Familial Autoinflammatory Syndromes, Pages 1666-1684.e4
Chapter 98 - Pathogenesis of Osteoarthritis, Pages 1685-1704.e8
Chapter 99 - Clinical Features of Osteoarthritis, Pages 1705-1718
Chapter 100 - Treatment of Osteoarthritis, Pages 1719-1729
Chapter 101 - Metabolic Bone Disease, Pages 1730-1750.e4
Chapter 102 - Proliferative Bone Diseases, Pages 1751-1763.e3
Chapter 103 - Osteonecrosis, Pages 1764-1787.e5
Chapter 104 - Relapsing Polychondritis, Pages 1788-1796
Chapter 105 - Heritable Diseases of Connective Tissue, Pages 1797-1815
Chapter 106 - Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, Pages 1816-1825
Chapter 107 - Clinical Features and Treatment of Juvenile Idiopathic Arthritis, Pages 1826-1843.e6
Chapter 108 - Pediatric Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Scleroderma, and Vasculitis, Pages 1844-1875.e8
Chapter 109 - Bacterial Arthritis, Pages 1876-1890
Chapter 110 - Lyme Disease, Pages 1891-1904.e4
Chapter 111 - Mycobacterial Infections of Bones and Joints, Pages 1905-1917
Chapter 112 - Fungal Infections of Bones and Joints, Pages 1918-1928.e3
Chapter 113 - Rheumatic Manifestations of Human Immunodeficiency Virus Infection, Pages 1929-1942
Chapter 114 - Viral Arthritis, Pages 1943-1955.e3
Chapter 115 - Rheumatic Fever and Post-streptococcal Arthritis, Pages 1956-1972
Chapter 116 - Amyloidosis, Pages 1973-1982
Chapter 117 - Sarcoidosis, Pages 1983-1996
Chapter 118 - Hemochromatosis, Pages 1997-2006
Chapter 119 - Hemophilic Arthropathy, Pages 2007-2017
Chapter 120 - Rheumatic Manifestations of Hemoglobinopathies, Pages 2018-2025
Chapter 121 - IgG4-Related Disease, Pages 2026-2036
Chapter 122 - Arthritis Accompanying Endocrine and Metabolic Disorders, Pages 2037-2047.e3
Chapter 123 - Musculoskeletal Syndromes in Malignancy, Pages 2048-2065.e6
Chapter 124 - Tumors and Tumor-like Lesions of Joints and Related Structures, Pages 2066-2086
Index, Pages I1-I69
